Answer
$y'=10(2x+1)^4$
Work Step by Step
Find y and u:
$y=u^5$
$u=2x+1$
First, find the derivative of y and u. Don't forget to apply chain rule for y':
$y'=5u^4\times u'$
$u'=2$
Then plug in u and u' into y':
$y'=5(2x+1)^4\times2=10(2x+1)^4$