Answer
$$ y'=16^ {\sin x} \cos x\ln 16.$$
Work Step by Step
Recall that $(a^x)'=a^x\ln{a}$
Recall that $(\sin x)'=\cos x$.
Since $ y=16^{\sin x}$, then by the chain rule, we have
$$ y'=16^ {\sin x} \cos x\ln 16.$$
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