Answer
$25x^6-4y^2$
Work Step by Step
Using the product of the sum and difference of like terms, $(a+b)(a-b)=a^2-b^2$, the given expression is equivalent to
\begin{align*}
&
(5x^3+2y)(5x^3-2y)
\\\\&=
(5x^3)^2-(2y)^2
\\\\&=
25x^6-4y^2
.\end{align*}