Answer
$10x^2-21xy+8y^2$
Work Step by Step
Using the FOIL Method, $(a+b)(c+d)=ac+ad+bc+bd$, the given expression simplifies to
\begin{align*}
&
(5x-8y)(2x-y)
\\\\&=
10x^2-5xy-16xy+8y^2
\\\\&=
10x^2-21xy+8y^2
.\end{align*}
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