Answer
$16x^2+8xz+z^2$
Work Step by Step
Using the square of a binomial, $(a+b)^2=a^2+2(a)(b)+b^2$, the given expression is equivalent to
\begin{align*}
&
(4x+z)^2
\\\\&
(4x)^2+2(4x)(z)+(z)^2
\\\\&
16x^2+8xz+z^2
.\end{align*}
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