Answer
$x=-4$
Work Step by Step
Express both sides of the equation with the same base. Once the bases are the same, then equate the exponents. That is,
\begin{array}{l}
3^x=\dfrac{1}{81}\\\\
3^x=\dfrac{1}{3^4}\\\\
3^x=3^{-4}\\\\
x=-4
.\end{array}