Answer
$x=-1$ , $x=-3$
Work Step by Step
Recognize 8 as a power of 2.
$ 2^{x^{2}+4x}=\displaystyle \frac{1}{2^{3}}\qquad$ ... apply $a^{-n}=\displaystyle \frac{1}{a^{n}}$
$ 2^{x^{2}+4x}=2^{-3}\qquad$ ... apply the exponential equality principle
$x^{2}+4x=-3$
$x^{2}+4x+3=0$
.. find factors of $c=3$ whose sum is $b=4$
... we find $+1$ and $+3.$
$(x+1)(x+3)=0$
$x=-1$ , $x=-3$