Answer
$(y^{6}/256x^{2})$.
Work Step by Step
$=((4x)^{2}y/xy^{4})^{-2}$
$=(16x^{2}y/xy^{4})^{-2}$
$=(16x/y^{3})^{-2}$ (since $a^{3}*a^{2}=a^{(3+2)}$)
$=(y^{3}/16x)^{2}$ (since $a^{-1}=1/a$)
$=(y^{(3*2)}/(16x)^{2})$ (since $(a/b)^{c}=(a^{c}/b^{c})$)
$=(y^{6}/256x^{2})$