Answer
$-16$
Work Step by Step
The general formula to calculate the determinate of a $2 \times 2$ matrix which has 2 rows and 2 coulmns is
$D=\begin{vmatrix}a&b\\c&d\end{vmatrix}=ad-bc$
Now,
$D=\begin{vmatrix}4&8\\5&6\end{vmatrix}=24-40=-16$