Answer
-(x^2-x-10)(x^2+x+10)
Work Step by Step
Using factoring techniques, then,
\begin{array}{l}
x^2+20x+100-x^4
\\=
(x^2+20x+100)-x^4
\\=
(x+10)^2-x^4
\\=
[(x+10)-x^2][(x+10)+x^2]
\\=
(x+10-x^2)(x+10+x^2)
\\=
(-x^2+x+10)(x^2+x+10)
\\=
-(x^2-x-10)(x^2+x+10)
.\end{array}