Answer
$f'(x) = \pi(2^x+1)^{\pi-1} 2^x\ln(2) $
Work Step by Step
If $f(x) = b^x$, then $f'(x) = b^x\ln(b)$
$f(x) = (2^x+1)^\pi$
Using General Power Rule and Chain Rule:
$f'(x) = \pi(2^x+1)^{\pi-1} 2^x\ln(2) $
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