Answer
$$ f'(x)= 4e^x(1+ e^{x})^3.$$
Work Step by Step
Recall that $(e^x)'=e^x$
Recall that $(x^n)'=nx^{n-1}$
Since we have
$$ f(x)=(1+ e^{x})^4$$
then the derivative $ f'(x)$, using the chain rule, is given by
$$ f'(x)=4(1+ e^{x})^3(1+ e^{x})'=4e^x(1+ e^{x})^3.$$