Answer
$-9$
Work Step by Step
Substituting $x=-4$, the given expression, $
3(2x-1)-4(2x+3)-(x+6)
,$ evaluates to
\begin{array}{l}\require{cancel}
3(2(-4)-1)-4(2(-4)+3)-((-4)+6)
\\\\=
3(-8-1)-4(-8+3)-(-4+6)
\\\\=
3(-9)-4(-5)-(2)
\\\\=
-27+20-2
\\\\=
-9
.\end{array}