Survival
In a zombie apocalypse, one thing remains imperative and that is avoiding getting bit by the undead. Though zombies might be brain-dead and slow, they still pose a huge threat in large numbers or through a sudden attack. Therefore, the character Columbus creates a set of rules acquired in the course of the pandemic for surviving the apocalypse. Other than the zombies, civilization has collapsed, and thereupon a lack of resources and basic needs to live on. As such, the survivors scavenge their way through America as supplies and resources become even scarcer. The male characters meet the two sisters through an instance of the survival of the fittest as the girls dupe them into procuring a means of transport.
Isolation
Before the survivors form the clique, each was on their own with the exception of Wichita and Little Rock. Even so, the duo experience loneliness and isolation since society has collapsed and most – if not all – humans are undead. For Columbus and Tallahassee, each was wandering trying to survive on their terms by isolating from other survivors too. Consequently, this force of habit makes them embrace a routine that fits their isolated lifestyle. For instance, they adopt city names to avoid deeper human connection with other survivors. This isolation is in part due to the trauma they suffered in the wake of the apocalypse, be it losing their loved ones or witnessing too much carnage.
Pop Culture
Following the release of the sequel Zombieland: Double Tap the franchise has proven to be meta-referential, setting itself apart from similar films. The first film set up the tone for pop culture references since it is full of self-referential instances in terms of its genre. Moreover, it incorporated common urban legends such as the myth behind the Twinkies regarding its shelf life. The famous Bill Murray cameo is the ultimate example of this theme that is prevalent throughout the film. Beyond the apparent examples, the film entails references that range from public figures, music, and other films.