Answer
$$x^6y^3z -3x^4y^4z-3x^2y^4z^2 +4x^2y^3z^3
$$.
Work Step by Step
By multiplying each term of the polynomial by the factor $x^2y^3z$ and then adding the products, we have
$$
x^2y^3z(x^4 - 3x^2y -3yz + 4z^2)\\
=x^2y^3z(x^4 )+x^2y^3z(- 3x^2y)+x^2y^3z( -3yz) +x^2y^3z( 4z^2)\\
=x^6y^3z -3x^4y^4z-3x^2y^4z^2 +4x^2y^3z^3
$$.