Answer
$(\frac{1}{4})^{-2}=16$
Work Step by Step
If $b\gt0$ and $b\ne1$, then $y=log_{b}x$ means $x=b^{y}$ for every $x$ and every real number $y$.
Therefore, $\log_{\frac{1}{4}}16=-2$ means $(\frac{1}{4})^{-2}=4^{2}=16$.
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