Answer
$-12x^{2}z
$
Work Step by Step
Using the laws of exponents, the given expression, $
-3xy^{-2}(4xy^2)z
$, simplifies to
\begin{array}{l}
(-3)(4)x^{1+1}y^{-2+2}z
\\\\=
-12x^{2}y^{0}z
\\\\=
-12x^{2}z
.\end{array}
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