Answer
$a=-6300000$
Work Step by Step
According to the Binomial Theorem, the 6th, that is, the ($5+1$)th term of $(2x-5y)^9$ is:
$_9C_5(2x)^{9-5}(-5y)^5=\frac{9!}{(9-5)!\times5!}(2x)^4(-3125)y^5=(126)(16)x^4(-3125)y^5=-6300000x^4y^5$
$ax^4y^5=-6300000x^4y^5$
$a=-6300000$