Answer
11325.4 Pa
Work Step by Step
Let's apply equation 11.4 $P_{2}=P_{1}+h\rho g$ to find the pressure in the brain.
$P_{2}=P_{1}+h\rho g$ ; Let's plug known values into this equation.
$16000\space Pa=P_{1}+(0.45\space m)(1060\space kg/m^{3})(9.8\space m/s^{2})$
$P_{1}=11325.4\space Pa$ (Pressure in the brain)