Answer
$x^{20}-25$
Work Step by Step
Using $(a+b)(a-b)=a^2-b^2$ or the special product of the sum and difference of like terms, the product of the given expression, $
(x^{10}+5)(x^{10}-5)
,$ is
\begin{array}{l}\require{cancel}
x^{10}(x^{10})-5(5)
\\\\=
x^{20}-25
.\end{array}