Answer
$16-s^2$
Work Step by Step
Using $(a+b)(a-b)=a^2-b^2$ or the special product of the sum and difference of like terms, the product of the given expression, $
(4+s)(4-s)
,$ is
\begin{array}{l}\require{cancel}
4(4)-s(s)
\\\\=
16-s^2
.\end{array}