Answer
$(x^{2n}+25)(x^{n}+5)(x^{n}-5)$
Work Step by Step
Using $a^2-b^2=(a+b)(a-b)$ or the factoring of the difference of 2 squares, then,
\begin{array}{l}
x^{4n}-625
\\=
(x^{2n}+25)(x^{2n}-25)
\\=
(x^{2n}+25)(x^{n}+5)(x^{n}-5)
.\end{array}