Answer
$(5x^n+9)(5x^n-9)$
Work Step by Step
Using $a^2-b^2=(a+b)(a-b)$ or the factoring of the difference of 2 squares, then,
\begin{array}{l}
25x^{2n}-81
\Rightarrow
(5x^n+9)(5x^n-9)
.\end{array}
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