Answer
$(x^2+9)(x+3)(x-3)$
Work Step by Step
Using $a^2-b^2=(a+b)(a-b)$, the factored form of the given expression, $
x^4-81
,$ is
\begin{array}{l}\require{cancel}
(x^2+9)(x^2-9)
.\end{array}
Since the second factor is still a difference of $2$ squares, using the same factoring technique, the completely factored form of the expression above is
\begin{array}{l}\require{cancel}
(x^2+9)(x+3)(x-3)
.\end{array}