Answer
$$x=-8,\:x=-2$$
Work Step by Step
Using the rules of logarithms to solve the equation, we find:
$$\log _4\left(\left(-x\right)\left(x+10\right)\right)=2 \\ \log _4\left(\left(-x\right)\left(x+10\right)\right)=\log _4\left(16\right) \\ -x\left(x+10\right)=16 \\ x=-8,\:x=-2$$
Checking for extraneous solutions, we see that both solutions valid.