Answer
$=\frac{a-3b}{a+4b}$
Work Step by Step
$\frac{a^2-5ab+6b^2}{a^2+2ab-8b^2}$
$=\frac{a^2-2ab-3ab+6b^2}{a^2+4ab-2ab-8b^2}$
$=\frac{(a-2b)(a-3b)}{(a-2b)(a+4b)}$
$=\frac{a-3b}{a+4b}$
The denominator of the original expression is 0 when $a = 2b$ or $a = -4b$. So the simplified form is $=\frac{a-3b}{a+4b}$, where $a \ne -4b$.