Execrate
Detest, condemn
Frailties
Disability, feebleness
Disdainful
Patronizing, scornful, haughty
Ascribed
Imputed, assigned
Oblique
Diagonal, slanting
Melancholy
Unhappiness, desolation
Anomaly
Peculiarity, oddity
Pauper
Insolvent, bankrupt
Abyss
Gulf, bottomless hole
Gruelling
Draining, exhausting, strenuous