Answer
The preparation of vaccine should consist either the attenuated or killed pathogens. The vaccine for HIV has not been successfully developed because of continued mutation of the virus, which renders it unrecognizable to the previously produced memory cells by vaccination.
Work Step by Step
The vaccine should be able to induce an immunological response by injecting either the attenuated or killed pathogens. The primary immune response is generated due to the administration of vaccines. The vaccine has been developed for a wide range of diseases, like poliovirus, chicken pox virus, measles, tetanus, and many more.
The vaccines are not successful against HIV due to a continued mutation of the virus. HIV is a lentivirus (a subgroup of retrovirus). The virus changes constantly, which renders it unrecognizable to the previously produced memory cells by vaccination.