Answer
The self-reactive B cells are negatively selected during the process of maturation. The possible risk of developing the autoimmune disease is enhanced due to the presence of these cells and it poses a serious threat to the survival of an individual.
Work Step by Step
Central tolerance is the phenomenon in which self-reactive B cells are negatively selected during the process of maturation. The central tolerance ability ensures that the B cells are unable to recognize self-antigens as an invader (foreign).
Central tolerance enhances the receptor diversity and it helps in destroying or inactivating the self-reactive B cells as this can lead to the development of an autoimmune disease. Peripheral tolerance also comes into play, if some self-reactive cells are left. The clonal deletion ensures that all the possible clones of self-reactive cells are deleted.
