Answer
$360$
Work Step by Step
The order of the letters matters here, so the situation involves permutation.
We know that $P(n,r)=\frac{n!}{(n-r)!}.$
Hence with $n=6$, $r=4$, then:
$P(6,4)=\frac{6!}{(6-4)!}=\frac{6\cdot5\cdot4\cdot3\cdot2!}{2!}=6\cdot5\cdot4\cdot3=360.$