Answer
In EXCEL, select a cell and enter "=COMBIN(50;8)"
$_{50}C_8=536878650$
Work Step by Step
$_{50}C_8=\frac{50!}{(50-8)!\times8!}=\frac{50\times49\times48\times47\times46\times45\times44\times43\times42!}{42!\times8\times7\times6\times5\times4\times3\times2\times1}=536878650$