Answer
$f(x)=2(x+1)(x-2)(x-4)$
Work Step by Step
If the function has x-intercepts $a,b,c$, then it has the form $f(x)=k(x-a)(x-b)(x-c)$.
Here the x-intercepts are $1,2,4$; hence $f(x)=k(x+1)(x-2)(x-4)$.
The function also goes through $(0,16)$; hence: $16=k(1)(-2)(-4)=8k\\k=2$
Hence, the function is $f(x)=2(x+1)(x-2)(x-4)$