Answer
$$-6$$
Work Step by Step
We evaluate the determinant of the matrix using Cramer's rule, which is listed on page 203. Doing this, we find:
$$\det \begin{pmatrix}2&-1\\ 4&-5\end{pmatrix} \\ 2\left(-5\right)-\left(-1\right)\cdot \:4
\\ -6$$