Answer
NAD+ is replenished with fermentation which is necessary so that all NAD+ requiring reactions of glycolysis can continue. NAD+ must be reduced in order for cellular respiration of more glucose to progress, so it has be replenished.
Work Step by Step
NAD+ is replenished with fermentation which is necessary so that all NAD+ requiring reactions of glycolysis can continue. NAD+ must be reduced in order for cellular respiration of more glucose to progress, so it must be replenished.