Answer
The regulatory T (Treg) cells are a necessary component for maintaining the population of T cells with the help of released cytokines and for decreasing the risk of autoimmune disorders. The number of Treg cells is low in hygienic areas, which thereby affects the self-reactive lymphocyte inhibition.
Work Step by Step
The regulation of T-cell population is performed by the Treg cells, as they modulate the immune system by releasing the cytokines. It helps in maintaining the tolerance toward self-antigens. This eventually decreases the risk of autoimmune disorders.
The suppression of effector T-cell proliferation is mediated by Treg cells. In the areas of proper sanitation, the risk of parasitic infection is rare. Thus, the number of Treg cells will be less and the self-reactive lymphocyte inhibition is affected. The chances of autoimmune disease are greatly enhanced due to the presence of less self-reactive lymphocytes.
