Biological Science (6th Edition)

Published by Benjamin Cummings
ISBN 10: 0321976495
ISBN 13: 978-0-32197-649-9

Chapter 48 - The Immune System in Animals - Review - Case Study - Page 1028: 12

Answer

The adaptive immune response is initiated against the foreign invader. In this case the IgE antibody production is greatly increased after challenging the organism with the parasitic worms as it sensitizes the mast cells. The mast cells are involved in the generation of an innate immune response. Thus, the response is activated against the parasitic worm infection.

Work Step by Step

The infection caused by the parasitic worms elicits the production of IgE (immunoglobulin) antibodies as a adaptive immune response . Human immunoglobulin E (IgE) is usually expressed on the surface of mature B cells and binds with the multivalent allergens to allergen-specific IgEs on sensitized effector cells. These interactions stimulate effector cell activation, produce potent inflammatory mediators, and elicit production of allergen-specific antibody responses. The IgE antibodies act a defense mechanism against the parasitic worms. The antibody production becomes a part of the humoral response of the adaptive immunity. IgE sensitizes the mast cells, which are a component of the innate immune response. The mast cells respond to the worms by releasing chemicals, such as histamine against the antigen, and promote inflammation.
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