Answer
A humoral response is necessary to create the adaptive antibody response that a vaccine is meant to create.
Work Step by Step
The purpose of a vaccine is to prevent a certain infection from being able to take hold in the body by training the immune system to preemptively develop a complete response to the infection. Memory B cells and antibodies circulating in the body are crucial to this process, as they identify the target pathogen and trigger an immune response to destroy it before it can infect the body and cause damage.