Answer
$\frac{1}{4}$
Work Step by Step
$\frac{16}{64}=\frac{2\times2\times2\times2}{2\times2\times2\times2\times2\times2}=\frac{2\times2\times2\times2}{2\times2\times2\times2}\times\frac{1}{2\times2}=1\times\frac{1}{4}=\frac{1}{4}$
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