Answer
$- \sin s \cos^4 s.$
Work Step by Step
By making use of Theorem 1 (FTC II), we have
$$
\frac{d}{d s} \int_{-6}^{\cos s} u^{4} d u=\left(\frac{d}{d v}\int_{-6}^{v}u^{4} d u\right)\frac{dv}{ds}= \cos^4 s \ (-\sin s)\\
=- \sin s \cos^4 s.
$$