Answer
$$-\frac{254}{7}.$$
Work Step by Step
We have
$$\int_{4}^{1} t^{5/2}dt=\frac{1}{7/2}t^{7/2}|_{4}^1=\frac{2}{7} -\frac{2}{7} 4^{7/2}\\=\frac{2}{7} -\frac{2^8}{7} =-\frac{254}{7}.$$
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