Answer
The simplified value is $ -128x^{19}y^{8} $.
Work Step by Step
The given expression is
$= \left ( 4x^{2}y^{4} \right )^{2}\left ( -2x^{5}y^{0} \right )^{3} $
Clear the parentheses.
$ = 16x^{4}y^{8} \times ( -8x^{15}y^{0} )$
Add the exponents of like terms.
$ =-128x^{4+15}y^{8+0}$
$ =-128x^{19}y^{8} $.