Answer
$-12 \sqrt{6}$
Work Step by Step
In order to simplify a radical, we consider the factors of the number inside of the radical. If any of these factors are perfect squares, meaning that their square root is a whole number, then we can simplify the radical. We know that 9 and 6 are factors of 54. We know that 9 is a perfect square, so we simplify:
$-4 \sqrt{9} \sqrt{6}=-12 \sqrt{6}$