Answer
$x=-7$
Work Step by Step
$3^{x+3}=\frac{1}{81}=81^{-1}$
$3^{x+3}=(3^4)^{-1}$
$3^{x+3}=3^{-4}$
Using the One-to-One Property:
$x+3=-4$
$x=-4-3$
$x=-7$
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