Answer
$y=-\frac{1}{2}(x-4)^2+1$
Work Step by Step
Vertex: $(h,k)=(4,1)$
Standard form:
$y=a(x-h)^2+k$
$y=a(x-4)^2+1$
Now, use the point $(2,-1)$ to find $a$:
$-1=a(2-4)^2+1$
$-1-1=a(4)$
$a=\frac{-2}{4}=-\frac{1}{2}$
$y=-\frac{1}{2}(x-4)^2+1$