In previous books in the Outlander series (Go Tell the Bees That I Am Gone is the ninth book in the series), Claire Randall, a nurse, traveled back in time to the 18th century. There, she met a man called Jamie Fraser, who she later married (despite already being married in another century).
At the start of Go Tell the Bees That I Am Gone, Claire and Jamie had been separated for twenty years as a result of the Jacobite Rising of 1743. After searching feverishly, the two finally reunite on Fraser's Ridge in North Carolina. There, they also reunite with their daughter, Brianna, and her husband, Roger. Finally, they could be one large, happy family, something that they have always wanted and strived for. But the looming American Revolution threatens their safety and their ability to stay with each other for any extended period of time.
People in North Carolina, as well as in the entire nation, begin to feel the ratcheting tension as a result of the looming Revolutionary War. North Carolina, like the entire country, is at a boiling point and is about ready to explode.
Simultaneously, Brianna and Roger begin to wonder if they made the right choice by coming to the 18th century instead of staying in the 20th century. Would the diseases of the 1700s kill them? Would they starve to death? Could the impending war somehow kill them?
While Brianna and Roger deal with the impacts of their decision, Jamie and Claire must contend with how to keep their family together, how to keep them safe, and how to deal with other outside sources that are affecting their lives.