Winona Ryder
Susanna Kaysen, the protagonist and the narrator, is played by Winona Ryder. She essentially plays a girl who attempts suicide and is hence committed to a psychiatric facility.
Angelina Jolie
Angelina Jolie almost overshadows Ryder, bringing the character of Lisa Rowe to life. She plays a dominating patient who influences the protagonist deeply.
Clea DuVall
Clea DuVall takes on the mask of Georgina Tuskin, a shy and friendly patient who is the roommate of the protagonist and also her good friend. She is hospitalized for schizophrenia, but is one of the patients in a better condition.
Brittany Murphy
Brittany Murphy plays the role of Daisy Randone, an enigmatic patient at the psychiatric facility who ends up killing herself. She is never seen mingling with any of the patients.
Elisabeth Moss
Elisabeth Moss plays Polly, a shy and peaceful patient who had been admitted after she poured gasoline on herself and set herself on fire.
