Irony of expectations
By running away from his problems and moving to Houston, Cam thinks that he will solve his problems. However, the only way one can solve their problems is to face them head-on. This irony underscores the cycle of self-deception that Cam deals with throughout much of the novel.
Irony of words
After Cam moves to Houston and starts to work in his friend TJ's bakery, the two start to but heads. On one hand, TJ only wants to help his friend. His suggestions and his offers to help are done from a good place. On the other, Cam is hurting and wants someone to take his pain and anger out on him. Still, despite both of their intentions, they say things they can never take back and which don't reflect who they are.
Irony of Kai's ghost
Even though Kai died in an unexpected car crash, preventing her from being present in anyone's life, his ghost—which can't exist—is seemingly always present in Cam's life. Although her presence is ironic, it underscores the depths of Cam's grief and shows how grief can make people act illogically.
The irony of TJ
TJ, one of Cam's best friends but not one of his family members, is more supportive than Cam's family. Typically, the family is supposed to support other family members when they are going through difficult things. But Cam's family is not there for him in a genuine way.