Irony of Kate's Reputation
As a result of Immari interference and the ease of accusing one crazy woman instead of suggesting a vast conspiracy, the media and therefore the world view Kate as the source of the deadly pandemic affecting the world. Ironically, Kate is their only chance of stopping the plague, as she is immune and is actively trying to combat it; they should be praising her, not condemning her.
Irony of the Ark of Malta
By the novel's end, the Ark of Malta is identified as the source of the broadcast that is causing the Atlantis plague. Ironically, the same ark actually casts a radius of protection around the surrounding area, turning Malta into a safe haven; the device that brings death also prevents it.
Irony of Janus and Ares
Janus and Ares are Atlanteans who have been present on Earth since the day Janus injected the Atlantis gene into the first humans. Despite their initial teamwork, they have slowly been drifting apart, and now they are nearly fierce enemies working to undermine each other. They are the saviors of humanity, but they are also about to be the cause of its destruction.
Irony of "Natural Selection"
The Immari claim that evolution is inevitable, and that natural selection will occur regardless of how people respond to it. Ironically, this selection is far from natural: it is the result of direct interference with human DNA by an alien civilization, and the presence of an activated gene is the sole determining factor in whether a person lives or dies from the Atlantis plague.
Irony of Janus's Name
Janus is the Atlantean who inhabits Kate Warner. She is the one who first injected humans with the Atlantis gene in order to save their lives, and even now she is working through Kate to save humanity from the Atlantis plague. "Janus" is a name from Roman mythology: Janus is the god of beginnings and transitions, which makes sense considering Janus's role in the present state of humanity. Ironically, Janus is also depicted as having two faces, and he is often portrayed as being wily and deceptive, which is entirely out of keeping with the character of Janus in this novel.
