Chapter 11 - The Cell Cycle and Cell Division - 11.7 - Unregulated Cell Division Can Lead to Cancer - 11.7 Recap - Learning Outcomes - Page 237: 1

Proto-oncogenes and tumor-suppressor genes play a vital role in cancer inhibition. These genes code for many proteins that control cell growth and proliferation. Mutations in these genes often allow cancer to develop. Most human tumors have deactivating mutations in proteins that normally affect cell cycle checkpoints, halting the step if damaged DNA is detected.

Proto-oncogenes and tumor-suppressor genes play a vital role in cancer inhibition. These genes code for many proteins that control cell growth and proliferation. Mutations in these genes often allow cancer to develop. Most human tumors have deactivating mutations in proteins that normally affect cell cycle checkpoints, halting the step if damaged DNA is detected.