Answer
A change in temperature or pH level surrounding an enzyme can cause it to become inactive because these changes can cause the enzyme to change shape, thus changing the shape of the active site where substrates bind. If the substrates cannot bind to the active site, the enzyme cannot catalyze the reaction.
Work Step by Step
A change in temperature or pH level surrounding an enzyme can cause it to become inactive because these changes can cause the enzyme to change shape, thus changing the shape of the active site where substrates bind. If the substrates cannot bind to the active site, the enzyme cannot catalyze the reaction.